Cyclic GMP kinase I modulates glucagon release from pancreatic α-cells Short Title: cGKI and glucagon release
نویسندگان
چکیده
1 FOR 923, Technische Universität München, Biedersteiner Str. 29, D-80802 München, Germany and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, D-81377 München, Germany 2 Institut für Pharmakologie und Toxikologie, Abteilung Pharmakologie und Experimentelle Therapie, Universitätsklinikum Tübingen, Wilhelmstr. 56, D-72074 Tübingen, Germany 3 Lehrstuhl für Physiologie I, Julius-Maximilians Universität Würzburg, Röntgenring 9, D-97070 Würzburg, Germany 4 Institut für Pharmakologie und Toxikologie, Technische Universität München, Biedersteiner Str. 29, D-80802 München, Germany 5 Institut für Pharmazie, Abteilung Pharmakologie, Toxikologie und Klinische Pharmazie, Universität Tübingen, Auf der Morgenstelle 8, D-72076 Tübingen, Germany
منابع مشابه
Cyclic GMP Kinase I Modulates Glucagon Release From Pancreatic α-Cells
OBJECTIVE The physiologic significance of the nitric oxide (NO)/cGMP signaling pathway in islets is unclear. We hypothesized that cGMP-dependent protein kinase type I (cGKI) is directly involved in the secretion of islet hormones and glucose homeostasis. RESEARCH DESIGN AND METHODS Gene-targeted mice that lack cGKI in islets (conventional cGKI mutants and cGKIα and Iβ rescue mice [α/βRM] that...
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Blood glucose levels are tightly controlled by the two peptide hormones glucagon and insulin. At hyperglycaemia, B-cells in the islets of Langerhans secrete insulin, whereas islet A-cells release glucagon at hypoglycaemia to stimulate e.g. glucose production in the liver. Previously, an important role for nitric oxide (NO) in the development of type-1 diabetes mellitus (insulin dependent diabet...
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Glucagon from the pancreatic α-cells is a major blood glucose-regulating hormone whose most important role is to prevent hypoglycaemia that can be life-threatening due to the brain's strong dependence on glucose as energy source. Lack of blood glucose-lowering insulin after malfunction or autoimmune destruction of the pancreatic β-cells is the recognized cause of diabetes, but recent evidence i...
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Highly purified glicentin, a 69-amino-acid-residue peptide isolated from porcine intestine that contains the full sequence of glucagon and is probably biosynthetically related to glucagon, is a substrate for cyclic-AMP-dependent protein kinase in a cell-free system. Glicentin-related pancreatic peptide (residues 1-30 of glicentin) and glucagon were not phosphorylated under the same reaction con...
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تاریخ انتشار 2010